Hydrochloric Acid → HCID 57779803, compound

HRID 1364193Notes

Reaction equation

HRID 1364193 reaction equation
C[O:2][C:3](=[O:25])[C@H:4]([NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][C:13]([F:16])([F:15])[F:14].[OH-].[Li+].Cl>O1CCCC1.CO>[C:21]([O:20][C:18]([NH:17][C@H:4]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][C:13]([F:14])([F:15])[F:16])[C:3]([OH:25])=[O:2])=[O:19])([CH3:24])([CH3:22])[CH3:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57779777HCID 57779777, compound

Product 1

HCID 57779803HCID 57779803, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the product from Step 2 (5.65 g, 15.6 mmol) in tetrahydrofuran (60 mL), methanol (20 mL) and aqueous 1 N lithium hydroxide solution (20 mL) was stirred at room temperature for 18 hours. The mixture was then poured into 0.5 N aqueous HCl solution and extracted with ethyl acetate. The organic extracts were combined, dried over MgSO4, filtered and concentrated in vacuo to give the desired product.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ccc8826b78ef4bc7bb7baef0a22c5c3f
Source dataset
uspto-grants-2011_02
Patent number
US07888345B2

Reaction notes

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