反应详情

A mixture of 4-pentynoic acid (210 mg, 2.14 mmol), morpholine hydrochloride (265 mg, 2.14 mmol), 1-hydroxybenzotriazol (338 mg, 2.50 mmol), WSC HCl (484 mg, 2.52 mmol), and triethylamine (0.37 ml, 2.65 mmol) in DMF (7 mL) was stirred for 1 h at room temperature. Water was added. The mixture was extracted with ethyl acetate-toluene, and the extracts were washed with water, dried over MgSO4, and concentrated. The residue was purified by silica gel column chromatography with 1:1 to 1:5 hexane/ethyl acetate to give the title compound (325 mg, 91%).

1. extractionThe mixture was extracted with ethyl acetate-toluene
2. washthe extracts were washed with water
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography with 1:1 to 1:5 hexane/ethyl acetate