Dichloromethane → N-[3-(4-chlorophenyl)sulfonyl-3-(2,5-difluorophenyl)propyl]methanesulfonamide

HRID 136943Notes

Reaction equation

HRID 136943 reaction equation
[C:95]([O:96][CH2:97][CH3:98])(=[O:99])[CH3:100].[CH3:23][S:24](=[O:25])(=[O:26])[NH:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34].[CH3:80][CH2:81][O:82][C:83](=[O:84])[CH3:85].[CH3:89][CH2:90][CH2:91][CH2:92][CH2:93][CH3:94].[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH2:12][CH2:13][OH:14])[c:15]2[c:16]([F:22])[cH:17][cH:18][c:19]([F:21])[cH:20]2)[cH:6][cH:7]1.[Cl:86][CH2:87][Cl:88].[O:54]=[C:55]([O:56][CH:57]([CH3:58])[CH3:59])[N:60]=[N:61][C:62]([O:63][CH:64]([CH3:65])[CH3:66])=[O:67].[O:75]1[CH2:76][CH2:77][CH2:78][CH2:79]1.[OH:68][C:69]([C:70]([F:71])([F:72])[F:73])=[O:74].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH2:12][CH2:13][NH:27][S:24]([CH3:23])(=[O:25])=[O:26])[c:15]2[c:16]([F:22])[cH:17][cH:18][c:19]([F:21])[cH:20]2)[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl Acetate2×HCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 10081367tert-Butyl methylsulfonylcarbamateHCID 230287923-[(4-Chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)-1-propanol

Product 1

HCID 59750787N-[3-(4-chlorophenyl)sulfonyl-3-(2,5-difluorophenyl)propyl]methanesulfonamide

Sources & evidence

ORD record
ord-f73a3fa415df46c18615eab7b44cd6ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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