反应详情

To a solution of 2-chloro-N-(3,5-dichloro-4-hydroxy-phenyl)-4-trifluoromethyl-benzenesulfonamide (421, 1.52 g, 3.41 mmol) in 10 mL of DMF, was added NaH (Aldrich, 288 mg, 60%, 7.2 mmol). The mixture was stirred for 10 min, then 2-chloro-6-nitrobenzothiazole (411, 765 mg, 3.56 mmol) was added. The reaction mixture was stirred until no 421 remained by TLC. The mixture was diluted with EtOAc and 2N HCl, extracted 3× with EtOAc (100 mL). The organic layers were washed twice with a brine solution (100 mL), dried over Na2SO4 and concentrated. The residue was purified by chromatography (15%-20% EtOAc/hexanes) to give 1.5 g (74%) of product.

1. stirringThe reaction mixture was stirred until no 421
2. extractionextracted 3× with EtOAc (100 mL)
3. washThe organic layers were washed twice with a brine solution (100 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe residue was purified by chromatography (15%-20% EtOAc/hexanes)