反应详情

DIAD (0.64 ml, 3.25 mmol) was added dropwise while stirring a mixture of (2S,4S)-1-tert-butoxycarbonyl-4-phenoxy-2-pyrrolidinylmethanol (1.16 g, 3.25 mmol), methyl 4-hydoxybenzoate (494 mg, 3.25 mmol) and triphenylphosphine (852 mg, 3.25 mmol) in THF (30 ml) at room temperature in a nitrogen gas stream. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 20 minutes and at 80° C. for 8 hours. After cooling, the reaction mixture was concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column (silica gel: 200 g), whereby from chloroform/acetone (20/1) eluate fractions, the title compound (2.07 g, 100%) was obtained as a colorless oil.

1. additionAfter completion of the dropwise addition
2. stirringthe reaction mixture was stirred at room temperature for 20 minutes and at 80° C. for 8 hours
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. customThe residue was purified by chromatography on a silica gel column (silica gel: 200 g), whereby from chloroform/acetone (20/1) eluate fractions