Nitrogen → 1,1-Dichloroethane

HRID 1380102Notes

Reaction equation

HRID 1380102 reaction equation
N1[CH:6]=[CH:5][CH:4]=[CH:3][CH2:2]1.N#N.F[C:10](F)(F)[C:11](O)=[O:12].[CH2:16]([Cl:18])[Cl:17]>C(Cl)(Cl)Cl>[C:2]1([O:12][CH3:11])[CH:16]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][CH:16]([Cl:18])[CH3:10]

Participants

7

Reactant 4

HCID 947NitrogenHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 407038Dihydropyridines

Product 2

HCID 63651,1-DichloroethaneHCID 7519Anisole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Dihydropyridine 2 (R8 =CH2 -C6H5 or ##STR4## Y=O or S, n=0 or 1) (Reaction Scheme I) is treated under an inert atmosphere (Ar or N2) with about 5-50 meq (preferably 10 meq trifluoroacetic acid neat or in the presence of a solvent (anisole, CH2Cl2, CHCl3, dichloroethane) at 25°-100° C. (preferably 25° C.) for about 10-60 minutes to obtain the Formula 1 compound. ##STR5##

Sources & evidence

ORD record
ord-0f066fe2f82144649d19667513a800d0
Source dataset
uspto-grants-1986_04
Patent number
US04579851

Reaction notes

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