Triethylamine → 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

HRID 1386020Notes

Reaction equation

HRID 1386020 reaction equation
[ClH:1].[C:2]([NH:9][CH2:10][CH2:11]CCCCN)(OC(C)(C)C)=O.O.O[N:19]1[C:23]2C=CC=CC=2N=N1.[CH2:28]([N:30]([CH2:33][CH3:34])[CH2:31]C)C>CN(C)C=O>[ClH:1].[CH2:10]([N:9]=[C:2]=[N:19][CH2:23][CH2:34][CH2:33][N:30]([CH3:28])[CH3:31])[CH3:11]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27960291-Hydroxybenzotriazole hydrateHCID 3017638tert-Butyl (6-aminohexyl)carbamate monohydrochloride

Product 1

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared according to the method described in Example 10, from N-boc-1,6-diamino-hexane hydrochloride (0.202 g), 1-hydroxybenzotriazole hydrate (0.065 g), triethylamine (0.11 ml), (2R)-1-[2-(6-(3-propanoic acid)naphthyloxy]-4-(3-pyridyl)-2-butanol (0.147 g, Example 9), dry N,N-dimethylformamide (20 ml) and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (0.092 g) to give the title compound as a pale yellow solid (0.116 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-eb767f1af9dc40b181d5d1fc5f5787ad
Source dataset
uspto-grants-2001_07
Patent number
US06265409B1

Reaction notes

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