Hydrochloric Acid → benzyl (2R)-2-(N-benzylamino)propionate hydrochloride

A solution of N-(tert-butoxycarbonyl)-D-alanine (3 g) in dimethylformamide (5 ml) was added dropwise to a stirred solution mixture of 60% sodium hydride (1.4 g) in dimethylformamide (5 ml) at ice-bath temperature. After stirring for 30 minutes at the same temperature, benzyl bromide (4.14 ml) was added and then the mixture was stirred for 1 hour at the same temperature and then for 6 hours at room temperature. The reaction mixture was poured into a mixture of dilute hydrochloric acid and ice-water, and extracted with diisopropyl ether. The extract was washed with aqueous sodium bicarbonate solution and brine successively and dried over magnesium sulfate. After evaporation of the solvent in vacuo, the residue was purified by column chromatography on silica gel eluting with a mixture of n-hexane and ethyl acetate (2:1) to give an oily product, which was dissolved in dichloromethane (40 ml). To the solution was added 4N hydrogen chloride in dioxane solution (7 ml) at ice-bath temperature. The resulting mixture was stirred for 1.5 hours at room temperature and then concentrated under reduced pressure to give benzyl (2R)-2-(N-benzylamino)propionate hydrochloride (2.2 g).

1. additionwas added
2. waitfor 6 hours at room temperature
3. extractionextracted with diisopropyl ether
4. washThe extract was washed with aqueous sodium bicarbonate solution and brine successively
5. dry with materialdried over magnesium sulfate
6. customAfter evaporation of the solvent in vacuo
7. customthe residue was purified by column chromatography on silica gel eluting with a mixture of n-hexane and ethyl acetate (2:1)
8. customto give an oily product, which
9. stirringThe resulting mixture was stirred for 1.5 hours at room temperature
10. concentrationconcentrated under reduced pressure

ORD record

ord-60ef6ba8c63340ae857c8c57b7982a66

Source dataset

uspto-grants-1999_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05883098