3-Hydroxypyridine → HCID 67567856, compound

HRID 1418597Notes

Reaction equation

HRID 1418597 reaction equation
[CH3:1]/[C:2](=[CH:8]\[C:9]1[CH:14]=[CH:13][C:12](F)=[C:11]([C:16]([F:19])([F:18])[F:17])[CH:10]=1)/[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(=O)([O-])[O-].[K+].[K+].[OH:26][C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1>CN(C=O)C>[N:29]1[CH:30]=[CH:31][CH:32]=[C:27]([O:26][C:12]2[CH:13]=[CH:14][C:9](/[CH:8]=[C:2](\[CH3:1])/[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:10][C:11]=2[C:16]([F:19])([F:18])[F:17])[CH:28]=1

Participants

5

Reactant 3

HCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 67567860HCID 67567860, compound

Product 1

HCID 67567856HCID 67567856, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3 b) The ester from 3 a, 3 eq. of potassium carbonate and 1.1 eq. of 3-hydroxypyridine were heated under reflux in DMF for 3 hours. After standard working up and purification, ethyl E-3-[4-(3-pyridyloxy)-3-(trifluoromethyl)phenyl]-2-methyl-propenoate was obtained.

Workup

  1. custompurification

Sources & evidence

ORD record
ord-59641d46c4c54f238ef8c486f3989ef6
Source dataset
uspto-grants-1999_03
Patent number
US05883133

Reaction notes

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