Ammonium Hydroxide → (R)-tert-butyl 2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylate

Temperature

-78 °C

A solution of tert-butyl pyrrolidine-1-carboxylate (1 mL 5.70 mmol) and (−)-sparteine (1.31 mL, 5.70 mmol) in anhydrous MTBE (30 mL) was first cooled to −78° C. under nitrogen, followed by addition of sec-butyl lithium (4.07 mL, 1.4M, 5.70 mmol) drop-wise over 15 minutes with a syringe, maintaining the temperature below −75° C. The pale yellowish solution was stirred at −78° C. for 3 hours before being treated with zinc chloride (3.80 mL, 1.0 M, 3.80 mmol) drop-wise over 15 minutes, maintaining the temperature below −73° C. The mixture was stirred at −78° C. for 30 minutes, then placed into an ambient temperature water bath and stirred for another hour. At this point a large amount of white precipitate was present. The mixture was treated with 3-bromo-2-chloro-5-fluoropyridine (1.00 g, 4.75 mmol) in MTBE (5 mL), followed by addition of palladium acetate (53 mg, 0.24 mmol) and tri-t-butylphosphine tetrafluoroborate (83 mg, 0.28 mmol). The mixture was allowed to stir at ambient temperature overnight to reach completion. The mixture was treated with NH4OH (1 mL), stirred for 30 minutes and filtered through GF/F paper, washing with MTBE. The filtrate was washed with 10% citric acid (30 mL) and the aqueous layer was back-washed with MTBE (2×30 mL). The combined organic phases were washed with brine (20 mL), dried (MgSO4), and concentrated to afford the crude product as dark yellowish oil. This crude material was purified on a silica 50 g Biotage SNAP cartridge eluting with 10% EtOAc in hexanes to afford the desired product as colorless oil (0.5 g, 35% yield). MS (apci) m/z=201.1 (M+H-Boc).

1. temperaturemaintaining the temperature below −75° C
2. temperaturemaintaining the temperature below −73° C
3. stirringThe mixture was stirred at −78° C. for 30 minutes
4. customplaced into an ambient temperature
5. stirringstirred for another hour
6. stirringto stir at ambient temperature overnight
7. stirringstirred for 30 minutes
8. filtrationfiltered through GF/F paper
9. washwashing with MTBE
10. washThe filtrate was washed with 10% citric acid (30 mL)
11. washthe aqueous layer was back-washed with MTBE (2×30 mL)
12. washThe combined organic phases were washed with brine (20 mL)
13. dry with materialdried (MgSO4)
14. concentrationconcentrated
15. customto afford the crude product as dark yellowish oil
16. customThis crude material was purified on a silica 50 g Biotage SNAP cartridge
17. washeluting with 10% EtOAc in hexanes

ORD record

ord-6fef450526694daa893ef7cbae0497e1

Source dataset

uspto-grants-2015_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08933084B2