反应详情

Mix 5-methanesulfonylamino-N-methyl-N-propyl-isophthalamic acid methyl ester (2.09 g, 6.36 mmol), iodomethane (1.35 g, 9.55 mmol), potassium carbonate (1.38 g, 10 mmol), and tetrabutylammonium bromide (206 mg, 0.64 mmol) in DMF (10 mL) at room temperature for 30 min. Dilute with ethyl acetate and wash with 10% aqueous potassium carbonate, 1 N lithium chloride and saturated aqueous sodium chloride. Dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 0:100 to 40:60 ethyl acetate:dichloromethane) to give the title compound as an oil.

1. washwash with 10% aqueous potassium carbonate, 1 N lithium chloride and saturated aqueous sodium chloride
2. dry with materialDry (magnesium sulfate)
3. concentrationconcentrate
4. custompurify
5. wash(silica gel chromatography, eluting with 0:100 to 40:60 ethyl acetate:dichloromethane)