反应详情

温度

50 °C

A mixture of quinolin-6-ol (0.58 g., 4 mmol), heptyl isocyanate (0.77 ml, 4.8 mmol), potassium carbonate (0.56 g., 4 mmol) and sodium iodide (0.60 g., 4 mmol) in dry dimethylformamide (2 ml) was stirred at 50° C. for 12 hours. The reaction mixture was diluted with water (5 ml), extracted with ethyl acetate (2×5 ml) and chromatographed on silica gel with chloroform as an eluant to give (1b), yield: 0.50 g. (43.7%).

1. extractionextracted with ethyl acetate (2×5 ml)
2. customchromatographed on silica gel with chloroform as an eluant