Hydrochloric Acid → HCID 3610739, compound

HRID 1457562Notes

Reaction equation

HRID 1457562 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH2:12][CH2:13][C:14]([OH:16])=[O:15].C(=O)([O-])[O-].[K+].[K+].Cl>C(O)COCCO.O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 750GlycineHCID 69772,5-DichloronitrobenzeneHCID 11430Potassium Carbonate

Product 1

HCID 3610739HCID 3610739, compoundYield 54.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8117Diethylene GlycolSolvent

Procedure

26.2 g (0.137 mol) of 2,5-dichloro-1-nitrobenzene, 20.6 g (0.274 mol) of glycine and 18.9 g (0.137 mol) of potassium carbonate were heated in 200 ml of diethylene glycol at 120° C. for 1 h. After cooling, 100 ml of water were added and the solution was acidified with 1M hydrochloric acid. The precipitate was filtered off with suction. 17.1 g (54%) of the product were obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitate was filtered off with suction

Sources & evidence

ORD record
ord-452f60cafb644a549c11ba456aa5bc05
Source dataset
uspto-grants-1998_12
Patent number
US05849743

Reaction notes

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