Hydrochloric Acid → HCID 10431897, compound

HRID 1461250Notes

Reaction equation

HRID 1461250 reaction equation
[CH3:1][N:2]([CH2:12][CH2:13][S:14][C:15]1[CH:28]=[CH:27][C:18]([CH:19]=[C:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[Mg].Cl.C([O-])(O)=O.[Na+]>CO.O1CCOCC1.O>[CH3:1][N:2]([CH2:12][CH2:13][S:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:27][CH:28]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 5462224MagnesiumHCID 54015419HCID 54015419, compound

Product 1

HCID 10431897HCID 10431897, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

5-(4-[2-(N-Methyl-N-(2-benzoxazolyl)amino)ethylthio]-benzylidene)-2,4-thiazolidinedione (2 g) was dissolved in a mixture of methanol (70 ml) and 1,4-dioxan (70 ml). Magnesium turnings (1.7 g) were added and the solution stirred until no more effervescence was observed. The mixture was added to water (300 ml), acidified (2M HCl) to form a solution, neutralised (saturated NaHCO3 solution) and extracted with dichloromethane (3×150 ml). The organic extracts were washed with brine

Workup

  1. customto form a solution
  2. extractionextracted with dichloromethane (3×150 ml)
  3. washThe organic extracts were washed with brine

Sources & evidence

ORD record
ord-0263135cdad64605b7ab90670fd5e825
Source dataset
uspto-grants-1991_12
Patent number
US05075300

Reaction notes

Loading…