Dimethylcarbamoyl Chloride → HCID 19089098, compound

HRID 1463999Notes

Reaction equation

HRID 1463999 reaction equation
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][CH:7]=2)[CH:3]=[CH:2]1.[CH3:9][N:10]([CH3:14])[C:11](Cl)=[O:12].C(N(CC)CC)C.C(OCC)(=O)C>O1CCCC1.O>[CH3:9][N:10]([CH3:14])[C:11]([N:1]1[C:8]2[N:4]([N:5]=[CH:6][CH:7]=2)[CH:3]=[CH:2]1)=[O:12]

Participants

7

Reactant 4

HCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 178419859HCID 178419859, compound

Product 1

HCID 19089098HCID 19089098, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1H-imidazo[1,2-b]pyrazole (2 g) in tetrahydrofuran (20 ml) were added N,N-dimethylcarbamoyl chloride (3.8 ml) and triethylamine (6.2 ml) at 20° C. under stirring. After stirring, the reaction mixture was poured into a mixture of ethyl acetate (30 ml) and cold water (50 ml). The ethyl acetate layer was separated, washed with water and a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and evaporated in vacuo to give 1-(N,N-dimethylcarbamoyl)-1H-imidazo[1,2-b]pyrazole (3.0 g).

Workup

  1. stirringAfter stirring
  2. customThe ethyl acetate layer was separated
  3. washwashed with water
  4. dry with materiala saturated aqueous solution of sodium chloride, dried over magnesium sulfate
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-300203e60aa542398a1e7fb1854218f9
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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