反应详情

In a 50 ml round bottomed flask, 2.55 g (13.3 mmol) of 1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride and 1.7 g of (8.2 mmol) phenylalanine were added to a solution of 1.87 g (9.3 mmol) of 2-(phenylseleno)ethanol in 20 ml of THF. The reaction mixture was then stirred for 12 hours at room temperature. The mixture was then diluted with 50 ml of ethyl acetate and extracted with 50 ml of a 0.5 M HCl solution. The organic phase was dried over sodium sulfate, filtered, and the solvent was removed in vacuo. Purification by column chromatography (PE:EE=2:1) yielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid.

1. extractionextracted with 50 ml of a 0.5 M HCl solution
2. dry with materialThe organic phase was dried over sodium sulfate
3. filtrationfiltered
4. customthe solvent was removed in vacuo
5. customPurification by column chromatography (PE:EE=2:1)
6. customyielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid