反应详情

温度

100 °C

To a solution of 1-(5-Bromo-2,3-dihydro-1H-inden-2-yl)-4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-2-one (60 mg, 0.132 mmol) in 2 mL of DMF was added Zn(CN)2 (15 mg, 0.132 mmol), Pd2(dba)3 (20 mg), TMEDA (10 mg), Xantphos (10 mg), and the mixture was stirred under microwave irradiation for 3 min at 100° C. The mixture was diluted with EtOAc and then filtrated. The filtrate was washed with brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by prep-TLC to give the title product. 1H-NMR (400 MHz, CDCl3) δ ppm 7.81 (d, J=7.8 Hz, 1H), 7.44-7.48 (m, 2H), 7.28˜7.34 (m, 3H), 5.49˜5.57 (m, 1H), 5.26 (s, 2H), 3.19˜3.28 (m, 4H), 2.88˜3.1 (m, 6H), 2.65˜2.7 (m, 4H).

1. filtrationfiltrated
2. washThe filtrate was washed with brine
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated
5. customThe residue was purified by prep-TLC