Hydrochloric Acid → Ethyl 7-bromo-2,2-dimethylheptanoate

Under Ar atmosphere at −78° C., to a solution of ethyl isobutyrate (124.0 g, 1.06 mol) and DMPU (5 mL) in THF (160 mL) was added LDA (750 mL, 2M). After 30 min, 1,5-dibromopentane (313 g, 1.32 mol) was added in a single portion. The reaction mixture was allowed to stir overnight, gradually warming to rt. The mixture was hydrolyzed with ice (500 g), saturated NH4Cl (400 mL) and aqueous HCl (6M, 400 mL), and the solution was extracted with Et2O (3×300 mL). The organic layers were washed with half saturated NaCl (2×300 mL), dried (MgSO4) and evaporated in vacuo. The remaining residue was purified by distillation under reduced pressure to give ethyl 7-bromo-2,2-dimethylheptanoate (97.4 g, 32%) as a colorless oil. bp: T=109-110° C. (p=1.5-2 Torr). 1H NMR (CDCl3): δ=4.15 (q, J=7.2 Hz, 2H), 3.40 (t, J=6.9 Hz, 2H), 1.90-1.83 (m, 2H), 1.55-1.37 (m, 4H), 1.25 (t, J=6.9 Hz, 3H), 1.30-1.22 (m, 2H), 1.16 (s, 6H). 13C NMR (CDCl3): δ=177.9, 60.3, 42.2, 40.5, 33.7, 32.7, 28.6, 25.2, 24.2, 14.3. FIRMS calcd for C11H22BrO2(MH+): 265.0803, found: 265.0816.

1. extractionthe solution was extracted with Et2O (3×300 mL)
2. washThe organic layers were washed with half saturated NaCl (2×300 mL)
3. dry with materialdried (MgSO4)
4. customevaporated in vacuo
5. distillationThe remaining residue was purified by distillation under reduced pressure

ORD record

ord-6359769b6f1c464f935f1068d22a71a5

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09006290B2