Lithium Hydroxide → HCID 66778978, compound

HRID 1470341Notes

Reaction equation

HRID 1470341 reaction equation
C[O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([C:10]2[O:18][C:17]3[C:12](=[N:13][CH:14]=[CH:15][C:16]=3[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:11]=2)[CH:7]=[C:6]([CH3:25])[CH:5]=1.[Li+].[OH-]>C1COCC1.O.Cl>[CH3:25][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([C:10]2[O:18][C:17]3[C:12](=[N:13][CH:14]=[CH:15][C:16]=3[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:11]=2)[CH:7]=1)[C:3]([OH:26])=[O:2]

Participants

6

Reactant 2

HCID 3939Lithium HydroxideHCID 66779782HCID 66779782, compound

Product 1

HCID 66778978HCID 66778978, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-Methyl-5-(7-phenyl-furo[3,2-b]pyridin-2-yl)-benzoic acid methyl ester (61.321 μmol) is dissolved in THF (300.00 μl) and LiOH 1M (122,600 μmol) is added. The reaction solution is stirred 26 h at RT and diluted with H2O (10 ml) and 1M HCl (122.6 μl) is added. The precipitate is filtered and washed with water and dried in vacuo. The product is obtained as colorless solid in quantitative yield; LCMS (ESI+) (method E): Rt 2.25 min, M+H+ 330.1 m/z.

Workup

  1. additionis added
  2. filtrationThe precipitate is filtered
  3. washwashed with water
  4. customdried in vacuo
  5. customThe product is obtained as colorless solid in quantitative yield

Sources & evidence

ORD record
ord-8549018430e64508afc9f896656af539
Source dataset
uspto-grants-2015_04
Patent number
US09006440B2

Reaction notes

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