反应详情

温度

60 °C

A mixture of 7-bromo-4-hydroxy-isoquinoline-3-carboxylic acid methyl ester (955.0 mg, 3.4 mmol), K2CO3 (1.2 g, 8.5 mmol), KI (56.2 mg, 0.3 mmol) and BnBr (0.6 mL, 4.7 mmol) in DMF (17 mL) was stirred at 60° C. for 16 hours. After cooling to room temperature, the mixture was diluted with EtOAc (100 mL) and H2O (100 mL). The layers were separated and the aqueous layer was extracted twice with EtOAc. The combined organic layers were dried over MgSO4, concentrated, and purified by flash chromatography (0-20% EtOAc/CH2Cl2) to give the title compound in 1.1 g. MS: (+) m/z 372.20 (M+1).

1. temperatureAfter cooling to room temperature
2. customThe layers were separated
3. extractionthe aqueous layer was extracted twice with EtOAc
4. dry with materialThe combined organic layers were dried over MgSO4
5. concentrationconcentrated
6. custompurified by flash chromatography (0-20% EtOAc/CH2Cl2)