反应详情

温度

125 °C

To a solution of 0.879 g (7 mmol) of 4-ethenyltetrahydro-2H-pyran-2-one in 5 mL triethylamine and 5 mL acetonitrile is added 0.081 g (0.36 mmol) Palladium-(II)-acetate followed by 0.659 g (2.5 mmol) tri-o-tolylphosphine and 0.76 mL (7.9 mmol) 3-bromopyridine and the mixture is heated at 125° C. for 20 hours in a sealed tube. It is then cooled, diluted with methylene chloride and washed with water. The organic phase is dried (MgSO4), filtered and evaporated to give a reddish oil which is flash chromatographed using ethyl acetate as eluent to obtain 4-[2-(3-pyridyl)ethenyl]tetrahydro-2H-pyran-2-one as an oil.

1. temperatureIt is then cooled
2. washwashed with water
3. dry with materialThe organic phase is dried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. customto give a reddish oil which
7. customchromatographed