Chloride → Tert-butyl 4-hydroxy-4-(1,3-thiazol-2-yl)cyclohexanecarboxylate
Reaction equation
[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH:4]([Mg+:5])([CH3:6])[CH3:7].[Cl-:1].[Cl-:3].[Li+:2].[O:13]=[C:14]1[CH2:15][CH2:16][CH:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]1.[cH:8]1[cH:9][s:10][cH:11][n:12]1>>[cH:8]1[cH:9][s:10][c:11]([C:14]2([OH:13])[CH2:15][CH2:16][CH:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]2)[n:12]1Participants
7
Sources & evidence
- ORD record
- ord-67c43c9613444c1f9ba68ce64cac0fd7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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