Iodine → HCID 178516694, compound

HRID 1504214Notes

Reaction equation

HRID 1504214 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][CH:9]=1.[I:18]I.C(=O)([O-])O.[Na+].S([O-])([O-])=O.[Na+].[Na+]>O.CN(C=O)C>[I:18][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:8]=1[OH:7])=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

8

Reactant 5

HCID 807IodineHCID 11430Potassium CarbonateHCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 178516385quinolin-4-ol

Product 1

HCID 178516694HCID 178516694, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Potassium carbonate(5.2 g) was added to a DMF solution(50 ml) of 4-hydroxy quinoline(5.0 g) and the mixture was stirred. Iodine (9.6 g) was added to the mixture, followed by stirring at room temperature for 3 hours. A saturated sodium hydrogencarbonate aqueous solution (73 ml) of 25% sodium sulfite, and water(50 ml) were added to the reaction mixture. The mixture was stirred and the precipitated insoluble matter was separated. The filtrate was washed with water and dried to give the title compound (9.0 g) as a white powder.

Workup

  1. stirringby stirring at room temperature for 3 hours
  2. stirringThe mixture was stirred
  3. customthe precipitated insoluble matter was separated
  4. washThe filtrate was washed with water
  5. customdried

Sources & evidence

ORD record
ord-41b2dbe034f84cb38c232e0562b9d961
Source dataset
uspto-grants-2015_12
Patent number
US09212187B2

Reaction notes

Loading…