Triethylamine → 6-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

HRID 151429Notes

Reaction equation

HRID 151429 reaction equation
[Br:1][c:2]1[c:3]([NH2:9])[n:4][c:5]([Cl:8])[cH:6][n:7]1.[C:10](#[CH:11])[Si:12]([CH3:13])([CH3:14])[CH3:15].[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[Cu:23][I:24].[Pd:25]([Cl:26])[Cl:27].[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1.[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1>>[c:2]1([C:11]#[C:10][Si:12]([CH3:13])([CH3:14])[CH3:15])[c:3]([NH2:9])[n:4][c:5]([Cl:8])[cH:6][n:7]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 179559913-Bromo-6-chloropyrazin-2-amine

Product 1

HCID 594244146-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

Sources & evidence

ORD record
ord-2ce4c7fe4e4a4e9baf84a24cb0265bd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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