反应详情

温度

110 °C

A suspension of piperidin-4-ol (12 g, 119 mmol), 2-chloro-5-propylpyrimidine (20.44 g, 131 mmol) and potassium carbonate (49.2 g, 356 mmol) in DMF (100 mL) was heated at 110° C. for 12 h. The mixture was diluted with EtOAc (250 ml) and washed three times with water, dried over Na2SO4, and concentrated to give a yellow oil. The oil was purified by flash chromatography (SiO2, 0-10% MeOH/CH2Cl2) to yield product (19 g, 86 mmol, 72.4% yield) as yellow solid. MS (ESI) 222.2 (M+1).

1. washwashed three times with water
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. customto give a yellow oil
5. customThe oil was purified by flash chromatography (SiO2, 0-10% MeOH/CH2Cl2)