反应详情

354 mg (2.6 mmol) K2CO3 was added to a solution of 700 mg (2.3 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in DMF (9 ml) and stirred for 60 min at RT. 190 μl (2.3 mmol) iodoethane was then added and the RS was stirred for a further 16 h at RT. The solution was subsequently diluted with water and EtOAc. The organic phase was separated, dried over MgSO4 and concentrated in a vacuum. After CC (EtOAc/hexane 1:3) of the residue, 168 mg (0.5 mmol, 22%) 2-ethoxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester was obtained.

1. stirringthe RS was stirred for a further 16 h at RT
2. customThe organic phase was separated
3. dry with materialdried over MgSO4
4. concentrationconcentrated in a vacuum