反应详情

A mixture of 3-methyl-4-(4,4,4-trifluoro-1-((4-(methoxycarbonyl)phenyl)amino)butyl)benzoic acid (725.6 mg), 1-amino-3,3-dimethylbutan-2-ol (430 mg), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (704 mg), 1-hydroxybenzotriazole monohydrate (562 mg), N,N-diisopropylethylamine (0.962 mL), 4-dimethylaminopyridine (22.42 mg) and DMF (4.5 mL) was stirred at room temperature overnight, and water was added. The mixture was extracted with ethyl acetate, and the extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate.

1. extractionThe mixture was extracted with ethyl acetate
2. washthe extract was washed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate