Hydrochloric Acid → HCID 117770030, compound

HRID 1526327Notes

Reaction equation

HRID 1526327 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])[C:4](=[O:16])[C:3]=1[CH:17]=O.Cl.[NH2:20][OH:21].Cl>CC(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])[C:4](=[O:16])[C:3]=1[CH:17]=[N:20][OH:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 443297Hydroxyamine hydrochlorideHCID 117770315HCID 117770315, compound

Product 1

HCID 117770030HCID 117770030, compoundYield 70.8%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-chloro-1-(2,6-difluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde obtained in Step C (1.07 g), hydroxylamine hydrochloride (414 mg), conc. hydrochloric acid (0.0120 mL) and 2-propanol (10 mL) was heated at 100° C. for 2 hr, and cooled to room temperature. The resulting solid was collected by filtration, and dried under reduced pressure to give the title compound (800 mg).

Workup

  1. temperaturecooled to room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-11a78b745a864f0f95034d162514567e
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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