Hydrochloric Acid → HCID 15672382, compound

HRID 1531443Notes

Reaction equation

HRID 1531443 reaction equation
[OH2:1].O.P([O-])(O)(O)=O.[Na+].OO.[Cl:11][C:12]1[CH:19]=[C:18]([Cl:20])[C:17]([C:21]2[C:25]([F:26])=[C:24]([O:27][CH:28]([F:30])[F:29])[N:23]([CH3:31])[N:22]=2)=[CH:16][C:13]=1[CH:14]=[O:15].[Cl-].[Na+].Cl>O.C(#N)C>[Cl:11][C:12]1[CH:19]=[C:18]([Cl:20])[C:17]([C:21]2[C:25]([F:26])=[C:24]([O:27][CH:28]([F:29])[F:30])[N:23]([CH3:31])[N:22]=2)=[CH:16][C:13]=1[C:14]([OH:1])=[O:15]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 5234Sodium ChlorideHCID 21254027HCID 21254027, compoundHCID 23673460Sodium Phosphate, Monobasic, Dihydrate

Product 1

HCID 15672382HCID 15672382, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6342AcetonitrileSolvent

Procedure

First, a solution of 0.85 g (5.5 mmol) of sodium dihydrogen phosphate dihydrate in 10 ml of water and then 2.7 ml of a 30% strength aqueous hydrogen peroxide solution were added dropwise to a solution of 7.4 g (22 mmol) of 2,4-dichloro-5-(5-difluoromethoxy-4-fluoro-1-methyl-1H-pyrazol-3-yl)benzaldehyde in 200 ml of acetonitrile. A solution of 2.9 g (33 mmol) of sodium chloride in 25 ml of water was then added dropwise to the reaction mixture in the course of 20 minutes. After the solution had been stirred for one hour, the resulting mixture was acidified with dilute hydrochloric acid. Finally, the solid product of value which had formed was filtered off and dried. Yield: 6.3 g.

Workup

  1. customFinally, the solid product of value which had formed
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-f2c09fccbef4432ab79f4866d105dc90
Source dataset
uspto-grants-2001_03
Patent number
US06197973B1

Reaction notes

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