M-Cresol → HCID 1540372, compound

HRID 1531930Notes

Reaction equation

HRID 1531930 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].Br[CH2:10][C:11]([O:13][CH3:14])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:8][C:2]1[CH:1]=[C:6]([CH:5]=[CH:4][CH:3]=1)[O:7][CH2:10][C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 342M-CresolHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetate

Product 1

HCID 1540372HCID 1540372, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of m-cresol (10.8 g), methyl bromoacetate (15.3 g) and potassium carbonate (69 g) in dimethylformamide (200 ml) was stirred overnight and partitioned between ethyl acetate and water. The organic phase was washed with water, dried (MgSO4) and evaporated. Purified by chromatography eluting with toluene. Yield 12.7 g.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe organic phase was washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customPurified by chromatography
  6. washeluting with toluene

Sources & evidence

ORD record
ord-7ef21d5ce979415bbe40009b3a9574ba
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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