Acetic Acid → Phenol, 5-bromo-2-fluoro-

HRID 1537982Notes

Reaction equation

HRID 1537982 reaction equation
[Br:16][c:17]1[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:11][CH2:12][CH2:13][CH2:14][Li:15].[CH3:1][C:2]1([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[NH:10]1.[CH3:24][O:25][B:26]([O:27][CH3:28])[O:29][CH3:30].[CH3:31][C:32](=[O:33])[OH:34].[OH:35][OH:36]>>[Br:16][c:17]1[cH:18][c:19]([OH:25])[c:20]([F:23])[cH:21][cH:22]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 8028TetrahydrofuranHCID 8470Trimethyl borateHCID 99931-Bromo-4-fluorobenzeneHCID 130352,2,6,6-TetramethylpiperidineHCID 178418339Butyllithium

Product 1

HCID 183421Phenol, 5-bromo-2-fluoro-

Sources & evidence

ORD record
ord-6936ee064c6244f3ad371702b84feb4e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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