Tetrahydrofuran → 2,5-Bis-hydroxymethyl-2,3-dihydrobenzofuran

HRID 1539637Notes

Reaction equation

HRID 1539637 reaction equation
[Al+3:18].[C:29]([O:30][CH2:31][CH3:32])(=[O:33])[CH3:34].[CH3:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].[H-:17].[H-:20].[H-:21].[H-:22].[I:35].[Li+:19].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1.[OH:1][CH2:2][CH:3]1[O:4][c:5]2[c:6]([cH:8][c:9]([C:12](=[O:13])[O:14][CH2:15][CH3:16])[cH:10][cH:11]2)[CH2:7]1>>[OH:1][CH2:2][CH:3]1[O:4][c:5]2[c:6]([cH:8][c:9]([CH2:12][OH:13])[cH:10][cH:11]2)[CH2:7]1

Participants

9

Reactant 8

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 24841Hydrogen iodideHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 13728720Ethyl 2-hydroxymethyl-2,3-dihydrobenzofuran-5-carboxylate

Product 1

HCID 201636522,5-Bis-hydroxymethyl-2,3-dihydrobenzofuran

Sources & evidence

ORD record
ord-03c8914d4dab4247a0d54f3a0e4b587c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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