Ammonium → 8-[2-(4-Fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:8])[cH:6][cH:7]1.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:9][CH2:10][CH2:11][CH2:12][Li:13].[Cl-:38].[NH4+:39].[O:14]=[C:15]1[CH:16]([N:21]2[CH2:22][CH2:23][C:24]3([CH:25]([c:30]4[cH:31][cH:32][cH:33][cH:34][cH:35]4)[CH2:26][NH:27][C:28]3=[O:29])[CH2:36][CH2:37]2)[CH2:17][CH2:18][CH2:19][CH2:20]1>>[c:2]1([C:15]2([OH:14])[CH:16]([N:21]3[CH2:22][CH2:23][C:24]4([CH:25]([c:30]5[cH:31][cH:32][cH:33][cH:34][cH:35]5)[CH2:26][NH:27][C:28]4=[O:29])[CH2:36][CH2:37]3)[CH2:17][CH2:18][CH2:19][CH2:20]2)[cH:3][cH:4][c:5]([F:8])[cH:6][cH:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-82e2e9a5d972406b8a230f483d46e5be
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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