Tetrahydrofuran → 3-Cyclopentyl-2-(4-fluoro-3-trifluoromethyl-phenyl)-propionic acid
Reaction equation
[CH3:31][N:32]1[CH2:33][CH2:34][CH2:35][N:36]([CH3:37])[C:38]1=[O:39].[CH3:45][N:46]1[CH2:47][CH2:48][CH2:49][N:50]([CH3:51])[C:52]1=[O:53].[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[F:9][c:10]1[c:11]([C:20]([F:21])([F:22])[F:23])[cH:12][c:13]([CH2:16][C:17](=[O:18])[OH:19])[cH:14][cH:15]1.[I:24][CH2:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[Li+:8].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[F:9][c:10]1[c:11]([C:20]([F:21])([F:22])[F:23])[cH:12][c:13]([CH:16]([C:17](=[O:18])[OH:19])[CH2:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30]2)[cH:14][cH:15]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c79609b2ecd34860b4e5594d2c6baaf7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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