Acetonitrile → 5-(4-Hydroxy-but-1-ynyl)-thiophene-2-carboxylic acid methyl ester
Reaction equation
[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[CH3:27][O:28][C:29](=[O:30])[c:31]1[s:32][c:33]([Br:36])[cH:34][cH:35]1.[CH3:48][C:49]#[N:50].[Cu:45]([I:46])[I:47].[OH:37][CH2:38][CH2:39][C:40]#[CH:41].[Pd:42]([Cl:43])[Cl:44].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[CH3:27][O:28][C:29](=[O:30])[c:31]1[s:32][c:33]([C:41]#[C:40][CH2:39][CH2:38][OH:37])[cH:34][cH:35]1Participants
8
Sources & evidence
- ORD record
- ord-afc262f1dddd4c3a8f65a78b3dac103b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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