Dimethylformamide → (4'-{4-[4-(Propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenylcarbamoyl}-6-trifluoromethoxy-biphenyl-3-yl)-carbamic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][cH:11][c:12]([O:24][C:25]([F:26])([F:27])[F:28])[c:13](-[c:15]2[cH:16][cH:17][c:18]([C:21](=[O:22])[OH:23])[cH:19][cH:20]2)[cH:14]1.[CH2:29]([CH2:30][CH3:31])[S:32](=[O:33])(=[O:34])[N:35]1[CH2:36][CH2:37][N:38]([CH2:41][c:42]2[cH:43][cH:44][c:45]([NH2:48])[cH:46][cH:47]2)[CH2:39][CH2:40]1.[CH3:49][CH2:50][N:51]=[C:52]=[N:53][CH2:54][CH2:55][CH2:56][N:57]([CH3:58])[CH3:59].[CH3:70][N:71]1[CH2:72][CH2:73][O:74][CH2:75][CH2:76]1.[O:77]=[CH:78][N:79]([CH3:80])[CH3:81].[OH:60][n:61]1[c:62]2[c:63]([cH:64][cH:65][cH:66][cH:67]2)[n:68][n:69]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][cH:11][c:12]([O:24][C:25]([F:26])([F:27])[F:28])[c:13](-[c:15]2[cH:16][cH:17][c:18]([C:21](=[O:23])[NH:48][c:45]3[cH:44][cH:43][c:42]([CH2:41][N:38]4[CH2:37][CH2:36][N:35]([S:32]([CH2:29][CH2:30][CH3:31])(=[O:33])=[O:34])[CH2:40][CH2:39]4)[cH:47][cH:46]3)[cH:19][cH:20]2)[cH:14]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-6e88763359b34d2bb06e4f1cefa16dd6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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