Acetic Acid → Ethyl 1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylate

HRID 1560544Notes

Reaction equation

HRID 1560544 reaction equation
[CH2:13]([CH3:14])[O:15][C:16](=[O:17])[CH:18]1[NH:19][CH:20]([c:23]2[cH:24][c:25]([F:31])[c:26]([F:30])[c:27]([F:29])[cH:28]2)[CH2:21][CH2:22]1.[CH3:34][CH2:35][O:36][C:37](=[O:38])[CH3:39].[CH3:40][OH:41].[CH3:9][C:10](=[O:11])[OH:12].[CH:1](=[O:2])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[Cl-:32].[NH4+:33].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[CH2:1]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[N:19]1[CH:18]([C:16]([O:15][CH2:13][CH3:14])=[O:17])[CH2:22][CH2:21][CH:20]1[c:23]1[cH:24][c:25]([F:31])[c:26]([F:30])[c:27]([F:29])[cH:28]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 223AmmoniumHCID 240BenzaldehydeHCID 312ChlorideHCID 887MethanolHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 77274851HCID 77274851, compound

Product 1

HCID 69048586Ethyl 1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylate

Sources & evidence

ORD record
ord-0ccde5cfd85f4890a13dc582825414b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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