Tetrahydrofuran → 4-[(8-Cyclopropyl-3 4-dihydro-4,4-dimethylspiro[2H-1-benzopyran-2,1'-cyclopropane]-6-yl)ethynyl]-2-fluoro-benzoic acid methyl ester
Reaction equation
[CH2:32]([N:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[CH3:38].[CH3:20][O:21][C:22]([c:23]1[c:24]([F:30])[cH:25][c:26]([I:29])[cH:27][cH:28]1)=[O:31].[CH3:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49].[CH3:91][CH2:92][O:93][C:94](=[O:95])[CH3:96].[CH:1]1([c:4]2[cH:5][c:6]([C:18]#[CH:19])[cH:7][c:8]3[c:13]2[O:12][C:11]2([CH2:10][C:9]3([CH3:16])[CH3:17])[CH2:14][CH2:15]2)[CH2:2][CH2:3]1.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[Pd:50]([Cl:51])[Cl:52].[c:53]1([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[cH:67][cH:68][cH:69][cH:70][cH:71]1.[c:72]1([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[cH:86][cH:87][cH:88][cH:89][cH:90]1>>[CH:1]1([c:4]2[cH:5][c:6]([C:18]#[C:19][c:26]3[cH:25][c:24]([F:30])[c:23]([C:22]([O:21][CH3:20])=[O:31])[cH:28][cH:27]3)[cH:7][c:8]3[c:13]2[O:12][C:11]2([CH2:10][C:9]3([CH3:16])[CH3:17])[CH2:14][CH2:15]2)[CH2:2][CH2:3]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-bfa512af7e5740ebb11b938b3ca78071
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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