Hydrochloric Acid → Ethyl 3-(5-chlorothiophen-2-yl)-3-oxopropanoate

HRID 1570392Notes

Reaction equation

HRID 1570392 reaction equation
[C:10]([n:11]1[cH:12][cH:13][n:14][cH:15]1)([n:16]1[cH:17][cH:18][n:19][cH:20]1)=[O:21].[C:23]([CH2:24][C:25]([O-:26])=[O:27])(=[O:28])[O:29][CH2:30][CH3:31].[CH3:38][CH2:39][O:40][C:41](=[O:42])[CH3:43].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1.[ClH:32].[Mg+:22].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[OH2:44]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:9])[CH2:24][C:23](=[O:28])[O:29][CH2:30][CH3:31])[s:6]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 682631,1'-CarbonyldiimidazoleHCID 950485-Chloro-2-thiophenecarboxylic acidHCID 3595298Propanedioic acid, monoethyl esterHCID 178506988HCID 178506988, compound

Product 1

HCID 22221391Ethyl 3-(5-chlorothiophen-2-yl)-3-oxopropanoate

Sources & evidence

ORD record
ord-c251449db6ad4477b78458fab9f8cb7b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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