Hydrochloric Acid → HCID 178429831, compound

HRID 1586676Notes

Reaction equation

HRID 1586676 reaction equation
O=C(C)C[N:4]1[C:8]([NH:9][C:10]([C:23]2C=CC=CC=2)([C:17]2C=CC=CC=2)C2C=CC=CC=2)=[CH:7][CH:6]=[N:5]1.Cl.C(OCC)(=O)C.C(=O)(O)[O-].[Na+]>CO.O1CCCC1>[CH3:23][C:10]1[NH:9][C:8]2[N:4]([CH:17]=1)[N:5]=[CH:6][CH:7]=2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 19089103HCID 19089103, compound

Product 1

HCID 178429831HCID 178429831, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-(2-oxopropyl)-5-triphenylmethylaminopyrazole (0.75 g) in methanol was added conc. hydrochloric acid (0.75 ml). The mixture was stirred for 2 hours. The reaction mixture was added to a mixture of ethyl acetate, tetrahydrofuran and ice-cold water, and the mixture was adjusted to pH 8 with sodium bicarbonate. The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was pulverized with diisopropyl ether to give 2-methyl-1H-imidazo[1,2-b]pyrazole.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0b1ca833743b4e819914723a75dbbe50
Source dataset
uspto-grants-1993_06
Patent number
US05215982

Reaction notes

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