反应详情

温度

60 °C

4-Hydroxybenzaldehyde (300 g) and 2-chloroethyl methyl ether (279 g) were dissolved in DMF (3 L) and potassium carbonate (408 g) was added. The mixture was stirred with heating at 60° C. for 16 hr. After the reaction, the reaction mixture was poured into water and liberated oil was extracted with ethyl acetate. The organic layer was washed with 1N aqueous sodium hydroxide solution and washed with saturated brine. The organic layer was dried over anhydrous magnesium sulfate. After drying, the residue was concentrated under reduced pressure to give 4-(2-methoxyethoxy)benzaldehyde as an oil (212 g).

1. customAfter the reaction
2. extractionwas extracted with ethyl acetate
3. washThe organic layer was washed with 1N aqueous sodium hydroxide solution
4. washwashed with saturated brine
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. customAfter drying
7. concentrationthe residue was concentrated under reduced pressure