Potassium Carbonate → HCID 69949873, compound

HRID 1596299Notes

Reaction equation

HRID 1596299 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:27])[CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][C:16](=[CH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[CH2:15][CH2:14]2)=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].CO[CH:36](OC)[N:37]([CH3:39])[CH3:38].N1CC[CH2:44][CH2:43]1>CN(C)C=O>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9](=[O:27])[C:10](=[CH:39][N:37]2[CH2:36][CH2:44][CH2:43][CH2:38]2)[CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][C:16](=[CH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[CH2:15][CH2:14]2)=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 78373Dimethylformamide dimethyl acetalHCID 21701715HCID 21701715, compound

Product 1

HCID 69949873HCID 69949873, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 1.96 g of 1-[4-(4-fluorophenyl)-4-oxobutyl]-4-(2-fluorobenzylidene)piperidine hydrochloride, 345 mg of anhydrous potassium carbonate, 5.0 ml of N,N-dimethylformamide dimethylacetal, 3.5 ml of pyrrolidine and 5.0 ml of N,N-dimethylformamide was stirred on an oil bath at 120° C. for 2.5 hours. The reaction solution was separated with ethyl acetate and water, and the organic layer was concentrated under reduced pressure to give a crude 1-[4-(4-fluorophenyl)-4-oxo-3-pyrrolidinomethylenebutyl]-4-(2-fluorobenzylidene)piperidine as an oil.

Workup

  1. customThe reaction solution was separated with ethyl acetate and water
  2. concentrationthe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-de3dad52ac9f4e0980f68b220757eafb
Source dataset
uspto-grants-2001_09
Patent number
US06291467B1

Reaction notes

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