反应详情

Acid 4-4 (100 mg, 0.36 mmol), amine 2-2 (105 mg, 0.36 mmol), EDC (88 mg., 0.46 mmol), HOBT (62 mg, 0.46 mmol) and NMM (137 μL, 1.2 mmol) were combined in 2 mL DMF. After 16 h the mixture was diluted with EtOAc, washed with water, sat. NaHCO3, 5% KHSO4, and brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 65% EtOAc/hexane) provided 4-5 as an oil.

1. washwashed with water, sat. NaHCO3, 5% KHSO4, and brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated