Hydrochloric Acid → HCID 19365553, compound

HRID 1600066Notes

Reaction equation

HRID 1600066 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:33][C:13]3[N:14]([CH2:24][C:25]4[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=4[F:32])[CH:15]=[C:16]([S:19]([CH:21]([CH3:23])[CH3:22])=[O:20])[C:17](=[O:18])[C:12]=3[C:11]=2[CH2:34][N:35]([CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH3:36])=[CH:6][CH:5]=1)([O-])=O.CO.Cl.C(=O)(O)[O-].[Na+]>[Fe].C(Cl)(Cl)Cl>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[S:33][C:13]3[N:14]([CH2:24][C:25]4[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=4[F:32])[CH:15]=[C:16]([S:19]([CH:21]([CH3:22])[CH3:23])=[O:20])[C:17](=[O:18])[C:12]=3[C:11]=2[CH2:34][N:35]([CH2:37][C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH3:36])=[CH:8][CH:9]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 516892Sodium BicarbonateHCID 19365588HCID 19365588, compound

Product 1

HCID 19365553HCID 19365553, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 6212ChloroformSolvent

Procedure

The compound (0.54 g, 0.87 mmol) obtained in Example 19 and iron powder (0.26 g, 4.3 mmol) were added to methanol (10 ml) and to the mixture conc.hydrogen chloride (5 ml) was added dropwise for one hour. The mixture was stirred for 5 hours under ice-cooling. To the reaction mixture saturated sodium bicarbonate (30 ml) was added carefully. After adding chloroform (50 ml) and Celite, the mixture was subjected to filtration.

Workup

  1. temperaturecooling
  2. filtrationthe mixture was subjected to filtration

Sources & evidence

ORD record
ord-633fe51c3c8d4ae7990b587f072dfdc3
Source dataset
uspto-grants-1998_04
Patent number
US05744479

Reaction notes

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