反应详情

Under ice-cooling, triethylamine (220 μl) was added to a mixture of 2-[3-(2-benzothiazolylmethoxy)benzoylamino]-4-[3-(4-chlorophenylsulfonyl)propyl]phenoxyacetic acid (400 mg, 0.62 mmol), glycine amide hydrochloride (86 mg), 1-hydroxybenzotriazole (125 mg), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (130 mg) and N,N-dimethylformamide (10 ml), and the mixture prepared was stirred at room temperature for 12 hours. Water and ethyl acetate were added to the reaction solution. The insoluble solid material formed was collected by filtration, washed with ethyl acetate, water, 1 N hydrochloric acid, water, ether, 1 N sodium hydroxide aqueous solution, water and ether in that order and then dried under reduced pressure. Acetonitrile (13 ml) was added to the resulting solid material, and the mixture was heated under reflux for 5 minutes with stirring and then cooled. The crystals formed were collected by filtration to give N-[[2-[3-(2-benzothiazolylmethoxy)benzoylamino]-4-[3-(4-chlorophenylsulfonyl)propyl]phenoxy]acetyl]glycine amide (170 mg, 0.24 mmol, 39%) as colorless crystals.

1. temperatureUnder ice-cooling
2. customthe mixture prepared
3. customThe insoluble solid material formed
4. filtrationwas collected by filtration
5. washwashed with ethyl acetate, water, 1 N hydrochloric acid, water, ether, 1 N sodium hydroxide aqueous solution, water and ether in that order
6. customdried under reduced pressure
7. additionAcetonitrile (13 ml) was added to the resulting solid material
8. temperaturethe mixture was heated
9. temperatureunder reflux for 5 minutes
10. stirringwith stirring
11. temperaturecooled
12. customThe crystals formed
13. filtrationwere collected by filtration