Ethyl Acrylate → 1-Pyrrolidinepropionic acid, ethyl ester

HRID 1603183Notes

Reaction equation

HRID 1603183 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[NH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1>C1COCC1>[N:8]1([CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 31268Pyrrolidine

Product 1

HCID 805901-Pyrrolidinepropionic acid, ethyl ester

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Ethyl acrylate (110.0 g; 1.1 mol) was dissolved in THF (250 ml). To this a solution of pyrrolidine (71.5 g; 1.0 mol) in THF (100 ml) was added dropwise in 75 minutes, after which stirring was continued for 3.5 hours at room temperature. The reaction mixture was evaporated by means of a rotary evaporator. The yield was 161.8 g (94%).

Workup

  1. customThe reaction mixture was evaporated by means of a rotary evaporator

Sources & evidence

ORD record
ord-beb027b3e00248df94c4c0355c105d2d
Source dataset
uspto-grants-1999_11
Patent number
US05986029

Reaction notes

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