Methane → HCID 21548856, compound

HRID 1605032Notes

Reaction equation

HRID 1605032 reaction equation
[C:1]([NH:9][CH2:10][C:11]([OH:13])=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([NH2:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].C>C(OCC)(=O)C>[CH2:14]([NH:26][C:11](=[O:13])[CH2:10][NH:9][C:1](=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

5

Reactant 3

HCID 297MethaneHCID 464Hippuric AcidHCID 13583Dodecylamine

Product 1

HCID 21548856HCID 21548856, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
160 °C

Procedure

A mixture consisting of 10 gm (0.056 mol) of N-benzoyl-glycine and 10.5 gm (0.056 mol) of n-dodecyl-amine was heated for 90 minutes at 160°C., while stirring. Thereafter, ethyl acetate and activated charcoal were added to the reaction mixture, and the mixture was vacuum-filtered while still hot. Upon cooling of the filtrate, a crystalline substance separated out which was collected and again recrystallized from ethyl acetate, yielding 11.9 gm (58% of theory) of the compound of the formula ##EQU4## having a melting point of 124°C.

Workup

  1. filtrationthe mixture was vacuum-filtered while still hot
  2. temperatureUpon cooling of the filtrate
  3. customa crystalline substance separated out which
  4. customwas collected
  5. customagain recrystallized from ethyl acetate
  6. customyielding 11.9 gm (58% of theory) of the compound of the formula

Sources & evidence

ORD record
ord-692741802b64453ab4b66d5f99f80a04
Source dataset
uspto-grants-1976_04
Patent number
US03948943

Reaction notes

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