Triethylamine → HCID 22789093, compound

HRID 1605826Notes

Reaction equation

HRID 1605826 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:20]([OH:22])=[O:21])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:30][CH2:31]I>CN(C)C=O>[Cl:30][CH2:31][O:21][C:20](=[O:22])[C@H:9]([CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)[NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 11644ChloroiodomethaneHCID 83169N-tert-Butoxycarbonyl-L-tryptophan

Product 1

HCID 22789093HCID 22789093, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was prepared by the method of Example 7A from N-tert.butoxycarbonyl-tryptophan, triethylamine, and chloroiodomethane in dimethylformamide; reaction time 4 hours. M.p. 155°-157°C.

Workup

  1. customreaction time 4 hours

Sources & evidence

ORD record
ord-5e4d95e3d6de4f3ebc58654e503d21ad
Source dataset
uspto-grants-1976_04
Patent number
US03951957

Reaction notes

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