Acetate → Methyl 3-(pyridin-3-yl)acrylate

HRID 160713Notes

Reaction equation

HRID 160713 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][cH:6][cH:7]1.[C:30]([CH:31]=[CH2:32])(=[O:33])[O:34][CH3:35].[C:43]([O-:44])(=[O:45])[CH3:46].[C:48]([O-:49])(=[O:50])[CH3:51].[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:52][C:53]#[N:54].[Pd+2:47].[c:8]1([CH3:9])[cH:10][cH:11][cH:12][cH:13][c:14]1[P:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[CH3:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1[CH3:29]>>[c:2]1([CH:32]=[CH:31][C:30](=[O:33])[O:34][CH3:35])[cH:3][n:4][cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 7294Methyl AcrylateHCID 8471TriethylamineHCID 122863-BromopyridineHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

Product 1

HCID 143845Methyl 3-(pyridin-3-yl)acrylate

Sources & evidence

ORD record
ord-96f4fb6d5a43489c896efbf5f6f56538
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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