Tetrahydrofuran → 1-(Tetrahydro-2H-pyran-2-yl)-5-((trimethylsilyl)ethynyl)-1H-indazole

HRID 160923Notes

Reaction equation

[Br:1][c:2]1[cH:3][c:4]2[cH:5][n:6][n:7]([CH:11]3[O:12][CH2:13][CH2:14][CH2:15][CH2:16]3)[c:8]2[cH:9][cH:10]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[CH3:17][Si:18]([CH3:19])([CH3:20])[C:21]#[CH:22].[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[Cu:23][I:24]>>[c:2]1([C:22]#[C:21][Si:18]([CH3:17])([CH3:19])[CH3:20])[cH:3][c:4]2[cH:5][n:6][n:7]([CH:11]3[O:12][CH2:13][CH2:14][CH2:15][CH2:16]3)[c:8]2[cH:9][cH:10]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 534338265-bromo-1-(oxan-2-yl)-1H-indazole

Product 1

HCID 667932011-(Tetrahydro-2H-pyran-2-yl)-5-((trimethylsilyl)ethynyl)-1H-indazole

Sources & evidence

ORD record: ord-3cdd83441ca147e58ea1fa6ec6eba0c2
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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